What more can I do?

and What else can I do?

I am at a loss to know what else to do. Is there anything else I can do? (An expression of desperation, not an inquiry.) Bob: Did you hear about the death in the Wilson family. Bill: Yes, I feel so helpless. I sent flowers. What more can I do? Bill: Is your child still sick? Mary: Yes. I'm giving her the right medicine. What more can I do?