v.1. To increase dramatically in amount: The stock shot up after the merger was announced.
2. To grow or get taller rapidly: Your daughter has really shot up since I last saw her.
3. To riddle someone or something with bullets: The sharpshooter shot up the target. Some gangsters drove by with machine guns and shot him up.
4. To damage or terrorize something, such as a town, by intense or random gunfire: The bandits got drunk and shot up the town. The gangsters shot the bar up when the owner refused to pay them.
5. Slang To inject oneself with a drug using a hypodermic needle: There were drug addicts shooting up in the hallway.
6. Slang To inject a drug into someone using a hypodermic needle: The nurse shot up the patient with a sedative. They shot her up with morphine.