1. Literally, driving a vehicle (and thus sitting at the steering wheel). Don't worry, Katie's at the wheel, and she is very good at driving in the snow.I'm so excited to finally be at the wheel of my own car!
2. By extension, in charge; acting the leader (of something). Jack is at the wheel, so I know they'll get this project done on time!
In command, in control. For example, Ann hated being told what to do; she wanted to be at the wheel by herself. The analogy here is to the steering wheel of an automobile or other vehicle, or the helm of a vessel. For a synonym, see at the helm.