be out of (one's) face

To be heavily intoxicated by drugs or alcohol, especially to the point of becoming unconscious, nonsensical, or out of control. I think someone might have spiked Jack's drink with some kind of drug because he's out of his face all of a sudden. Jane always gets really violent when she's out of her face like that. I had to take my brother away from the party because he was out of his face on LSD.