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3. be out of (one's) skull

be out of (one's) skull

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be out of (one's) skull

To be heavily intoxicated by drugs or alcohol, especially to the point of becoming unconscious, nonsensical, or out of control. Jane always gets really violent when she's out of her skull like that. I had to take my brother away from the party because he was out of his skull on LSD.

See also: of, out, skull