v.1. To move through the air, leaving some location: The birds flew out of their nest. Yesterday we flew out of London and arrived in New York. The pilot flew the soldiers out quickly.
2. To operate aircraft using some place as a central landing area: This new airline flies out of Boston and already has 20 destination cities.
3. Baseball To be called out by hitting a fly ball that is caught by the other team: The batter swung at the first pitch and flied out.