interact with someone
to converse with and exchange ideas with someone. In act two, I want Terri to interact with Amy a little more. They act as if they never even met each other. The students will interact with one another in their study projects.
interact with something
to have a reciprocal action with something; to react with something. (Often refers to the negative consequences of interaction.) Witt this drug interact with coffee? This drug will not interact with your current medication.