v.1. To shut or make something secure with or as if with locks: We locked the house up and went on vacation. I locked up my bike and went into the store. The owner locks up every day at 5:00.
2. To confine or exclude something or someone by or as if by means of a lock: We locked up the dog for the night. The guards locked the criminal up in the cell. All our savings are locked up in a retirement account.
3. To become fixed in place so that movement or escape is impossible; be immobilized: I was so nervous that my knees locked up and I couldn't walk. The car's brakes locked up, and it skidded to a halt.