Fig. to worry about someone or something a lot, sometimes when one should be sleeping. (Often used with any and the negative.) Yes, Kelly is in a little bit of trouble, but I'm not going to lose any sleep over her.Don't lose any sleep over the matter.I refuse to lose sleep about it.
Worry about, as in It's too bad the experiment failed, but I'm not going to lose sleep over it. This expression, often put negatively, alludes to actual insomnia caused by anxiety. [First half of 1900s]