v.1. To remove or pluck something from a surface: I picked off the price tag before wrapping the gift. We picked the dead leaves off the plant.
2. To shoot and kill something or someone with a gun, especially from a distance: The hunter picked the ducks off one by one. The sniper picked off an enemy soldier.
3. Baseball To throw the ball to an occupied base and put out a runner who is taking a lead: The catcher picked off the runner as he was trying to steal a base. The runner took a big lead, and the pitcher picked her off at first base.
4. Sports To intercept something, as a pass in American football: The cornerback picked off an errant pass and ran it back for a touchdown. The quarterback threw a low pass and a linebacker picked it off.