1. and popsie n. an ampoule of amyl nitrite, a drug that is inhaled when the ampoule is broken. (Drugs. Often plural.) You got any popsies I can have?
2. Go to pill-popper.
3. n. a handgun. (Underworld. From the sound of a gunshot.) He carries his popper under his coat.
4. n. a can of beer (in a pop-top can). You ready for another popper, Tom?