v. Slang 1. To make a mistake; blunder: I screwed up and delivered the package to the wrong address.
2. To injure, damage, or interfere negatively with something: Lifting those boxes really screwed up my back. I gave them detailed instructions, but they still screwed the project up.
3. To make someone neurotic or mentally disturbed: War can really screw up the survivors. Prison really screwed him up. She was screwed up by her parents' divorce.
4. To twist or deform something: The jester screwed up his face and gave a mocking reply. She screwed her eyes up and tried to read the sign.
5. To muster or summon up something: I screwed up my courage and went out on the stage.