v.1. To insert or fix something securely: The tailor patched my jacket and set in a new liner. I put the stakes in the ground and set them in with a mallet.
2. To become established as an internal or external condition, especially one that brings suffering or hardship to a person or group of people: Panic set in when the people realized the building was on fire. We must put a bandage on your wound before an infection sets in. We need wood for the fire now that winter is setting in.
3. To move toward the shore. Used of wind or water: After nightfall, the wind set in.