v.1. To fill some area with smoke: We forgot to open the flue, and the fire smoked up the room. The pot roast was left cooking too long, and it smoked the whole house up.
2. Slang To smoke marijuana: The members of the band would smoke up after each show.
3. Slang To provide someone or some group of people with marijuana to smoke: They smoked us up for the party, but it made us fall asleep.