| Abbreviation | Definition |
|---|---|
| SCRL | South Central Regional Library |
| SCRL | South County Regional Library |
| SCRLC | South Central Research Library Council (Ithaca, NY) |
| SCROLL | Supreme Court Records On Line Library |
| SCSL | Scientific Computing Software Library |
| SCSL | South Carolina State Library |
| SCTL | Solaris compatible Thread Library |
| SDCL | San Diego Conversation Library |
| SDCL | San Diego County Library |
| SDCL | San Diego County Library's |
| SDL | Simple DirectMedia Library |
| SDLA | South Dakota Library Association |
| SDLC | Scottish Digital Library Consortium |
| SDLC | Syrian Digital Library of Cuneiform |
| SDLL | San Diego Law Library |
| SDLS | Seismic Data Library System |
| SEAL | Simple Encrypted Arithmetic Library |
| SEALINGPLATE | A small disk or wafer of wax, lead, or paper bearing such an imprint and affixed to a document to prove authenticity or to secure it. |
| SEDL | Standards and Engineering Digital Library |
| SEER | Signpost, Example, Expand, Relate |