| Abbreviation | Definition |
|---|---|
| SOWKE | Sound Works International |
| SPA | Scan Predict And Act |
| SPAAF | Singapore Airlines |
| SPAB | Spacehab, Inc. |
| SPAB | Spacehab, Incorporated (de-listed) |
| SPAB | Spacehab, Incorporated (de-listed) |
| SPAIE | Sports Arenas, Inc. |
| SPAIE | Sports Arenas, Incorporated (de-listed) |
| SPAIE | Sports Arenas, Incorporated (de-listed) |
| SPAN | Span America Medical Systems, Inc. |
| SPAN | Span America Medical Systems, Incorporated (de-listed) |
| SPAN | Span America Medical Systems, Incorporated (de-listed) |
| SPANF | Singapore Airlines, LTD. |
| SPAR | Spartan Motors, Inc. |
| SPAWE | S P A International, Inc. |
| SPAZ | Spatializer Audio Labs |
| SPBI | Fibermark, Inc. |
| SPCH | Sport Chalet, Inc. |
| SPCL | Space Launches Financial, Inc. |
| SPCP | Spectrum Pharmaceutical |