| Abbreviation | Definition |
|---|---|
| DDGER | District Deputy Grand Exalted Ruler |
| DDI | Developmental Disabilities Institute |
| DDI | Diamond Development Initiatives |
| DDOOH | Dave Dravecky's Outreach Of Hope |
| DDPO | Drunk Driving Prevention Organization |
| DDR | Detroit Dog Rescue |
| DDR | Developmental Delay Resources |
| DDRA | Dorothy Dunnett Readers Association |
| DDRA | Dual Disorders Recovery Achievers |
| DDRB | Developmental Disabilities Resource Board |
| DDSC | Durham Divers Scuba Club |
| DEBRA | Dystrophic Epidermolysis Bullosa Research Association |
| DEC | Disasters Emergency Committee |
| DEC | District Effectiveness and Compliance |
| DECMH | Detroit East Community Mental Health |
| DECMHC | Detroit East Community Mental Health Center |
| DEF | Days End Farm |
| DEFHR | Days End Farm Horse Rescue |
| DEHS | Defence Electronics History Society |
| DEI | Detroit Entrepreneurship Institute, Inc. |