| Abbreviation | Definition |
|---|---|
| SPDR | Single Player Demo Release |
| SPEAR | Shogi Pattern Evaluator And Recognizer |
| Spec | Speckled Trout |
| SPECIAL | Strength, Perception, Endurance, Charisma, Intelligence, Agility, and Luck |
| SPECIAL | Strength, Perception, Endurance, Charisma, Intelligence, and Luck |
| SPECTRA | Sportsmanship, Participation, Excellence, Character, Teamwork, Respect, and Achievement |
| SPG | Shots Per Game |
| SPG | South Park Game |
| SPGC | Spring Valley Golf Course |
| SPGL | Semi-Pro Gaming League |
| SPICE | Supervised Personal Introduction to Custom Exercise |
| SPIN | Safe Pedaling In Nevada |
| SPL | Scottish Premier League |
| SPM | Schmidt Peterson Motorsports |
| SPOOK | Sheffield Postgrads Occasional Orienteering Klub |
| SPORT | Specificity, Progression, Overload, Regression, Tedium |
| SPORT | Sport Performance and Orthopedic Rehabilitation Team |
| SPORT | Sports Performance Orhopedic Rehab And Training |
| SPORTSMAN | Sportsmen's |
| SPORTSPEOPLE | Sports People's |