| Abbreviation | Definition |
|---|---|
| OSC | Optimizing Sisal Compiler |
| OSCAR | Open Standard Codes And Routine |
| OSCAR | Open Standard Codes And Routines |
| OSD | Outsourced Software Development |
| OSF | Open Software Foundation |
| OSG | Object Systems Group |
| OSG | Office of the Solicitor General |
| OSG | Online Strategy Guide |
| OSG | Online Support Group |
| OSG | Open Scene Graph |
| OSG | Open Systems Group |
| OSGP | Ohio Supercomputer Graphics Project |
| OSI | Open Source Initiative |
| OSI | Open System Interface |
| OSIRM | OSI Reference Model |
| OSIS | Operational Support Information System |
| OSK | On Screen Keyboard |
| OSK | Os Starter Kit |
| OSK | Outlook Survival Kit |
| OSL | Object Selection Language |