| Abbreviation | Definition |
|---|---|
| HLSDK | Half-Life Software Development Kit |
| HLSS | Half Life Sound Selector |
| HLT | High Level Tests |
| HLTL | High-Level Test Language |
| HLU | Horizontal LookUp |
| HM | Help Machine |
| HMS | Hotel Management Software |
| HMS | Hypertension Management Software |
| HMSB | HAZMAT Sign Builder |
| HMSE | Highpower Management System Enterpise |
| HMSE | Hotel Management Software Environment |
| HMSL | Hierarchical Music Specification Language |
| HMT | Halo Map Tool |
| HMTS | Humboldt Material Testing Software |
| HMVC | Hierarchical modelviewcontroller |
| HMVC | Hierarchical model–view–controller |
| HNG | Host New Goodies |
| HOC | Human Occupation Construct |
| HOCON | Human-Optimized Config Object Notation |
| HOL | High-Order Language |