| Abbreviation | Definition |
|---|---|
| MDSD | Model Driven Software Development |
| MDSE | Masters Diploma in Software Engineering |
| MDSE | Micromaster Defensor Special Edition |
| MDSE | Model Driven Software Engineering |
| MDSM | Model Driven Software Migration |
| MDSN | Model Driven Software Network |
| MDSP | Metar Decoder Software Package |
| MDT | Microsoft Deployment Toolkit |
| MDT | Mod Development Toolkit |
| MDTC | MicroSoft Distributed Transaction Coordinator |
| ME | Mass Effect |
| ME | Microsoft Explorer |
| ME | Millennium Edition |
| ME | Millennium Edition (Version 4.9 of Microsoft Windows) |
| ME | Mobile Edition |
| ME | Multi-Environment |
| MEA | Multiple Engine Architecture |
| MEC | Microsoft Experience Center |
| MECCA | Multimedia Entertainment Control Center Application |
| MED | Microsoft Enterprise Desktop |