| Abbreviation | Definition |
|---|---|
| SPE | System Processing Engine |
| SPEAD | Step Potential Equilibria And Dynamics (molecular dynamics simulation software) |
| SPEED | Saving, Printing, Entering, Editing, and Deleting |
| SPEED | Software Processes Easy Efficient Dedicated |
| SPEF | SOAP Profile Enabling Framework |
| SPELL | Software Process Evo Lutionary Language |
| SPELL | Software Process EvoLutionary Language |
| SPEM | Software & Systems Process Engineering Metamodel |
| SPEM | Software Process Engineering Metamodel |
| SPF | Safety Promise Found |
| SPF | Sunbelt Personal Firewall |
| SPI | Software Patent Institute |
| SPICE | Smart Personalisation And Integrated Card Encoding |
| SPICE | Software Process Improvement and Capability |
| SPICE | Software Process Improvement And Capability Evaluation |
| SPIDER | The Strathclyde Personal Interactive Development And Educational Resource |
| SPIF | Software Package Info File |
| SPIL | Software Prototype and Integration Laboratory |
| SPIN | Software Process Improvement Network |
| SPIRS | Silver Platter Information Retrieval Software |