| Abbreviation | Definition |
|---|---|
| COAST | Cache On A STick |
| COBOL | COmmon Business Operating Language |
| COC | Certified Outpatient Coding |
| COCN | Committee on Coding and Nomenclature |
| COCOMO | Constructive Cost Model |
| COD | Clemson Open Developers |
| CODA | Confirmation of Destructive Action |
| CODAS | Constrained Optimisation Design of Aerodynamic Shapes |
| COE | Common Office Environment |
| COED | COmmunications and EDiting Project |
| COFI | Callista Open Finance Interface |
| COGS | Contractors of Gearbox Software |
| COL | Caldera Open LINUX |
| COLA | Collaborative Object Lookup Application |
| COLDET | Collision Detection |
| COMOS | Component Object Server |
| COMPASS | CD Online Multimedia Proposal And Sales System |
| COMPASS | Computerized Model for Predicting and Analyzing Support Structures |
| COMPUTER | Commonly Operated Machine Particularly Used in Technical Education and Reasearch |
| ConEc | Context Encoders |