| Abbreviation | Definition |
|---|---|
| OSB(CDRH) | Office of Surveillance and Biometrics (CDRH) |
| OSB(CFSAN) | Office Services Branch (CFSAN) |
| OSC | Office of Surveillance and Compliance |
| OSC(CVM) | Office of Surveillance and Compliance (CVM) |
| OSCAR | ORACLE System for Center Automation and Retrieval |
| OSCI | Office of SCIence |
| OSCI(CFSAN) | Office of Science (CFSAN) |
| OSDB(CDRH) | Orthopedic Spine Devices Branch (CDRH) |
| OSD-HD | Office of the Secretary of Defense for Homeland Defense |
| OSE | Office of Surveillance and Epidemiology |
| OSE(CDER) | Office of Surveillance and Epidemiology (CDER) |
| OSEL | Office of Science and Engineering Laboratories |
| OSG | Office of the Surgeon General |
| OSHA | Occupational Safety and Health Administration (U.S. Department of Labor) |
| OSHC | Office of Science and Health Coordination |
| OSHC(OC) | Office of Science and Health Coordination (OC) |
| OSHI | Office of Special Health Issues |
| OSHI(OC) | Office of Special Health Issues (OC) |
| OSMP | Office of Special Medical Programs |
| OSO | Office of Security Operations |