| Abbreviation | Definition |
|---|---|
| SPICE | Smart Precise Impact Cost Effective (munitions) |
| SPICE | Smart Precise Impact & Cost Effective (munitions) |
| SPID | Strategic Power Infrastructure Defense |
| SPIN | SPecial INstructions |
| SPINS | Special Instructions |
| SPINTCOM | SPecial INTelligence COMmunications |
| SPINTCOMM | Special Intelligence Communications Handling System |
| SPIR | Spare Parts Interchangeability Report |
| SPIRE | Simulation of Passive Infrared Equipment |
| SPIREP | SPecial Intelligence REPort |
| SPIREP | Spot Intelligence Report |
| SPIRIT | Special-Purpose Integrated Remote Intelligence Terminal |
| SPIRIT | Spectral Infrared Interferometric Telescope |
| SPIT | Special Projects Intervention Team |
| SPIT | Surveillance Promises Interrogation And Threats |
| SPL | Software Products Library |
| SPLA | Sudan People's Liberation Army |
| SPLA/M | Sudan People's Liberation Army/Movement |
| SPLAT | Self- Propelled Loader And Trailer |
| SPLL | Self Propelled Loader Launcher |