| Abbreviation | Definition |
|---|---|
| DY | Deputy Director |
| DYN | DYNamic |
| E | East |
| E | Eastern |
| E | Eccentricity |
| E | Elevation angle |
| E | Engine |
| E | Exempt |
| E | Exploration |
| E&D | Engineering and Development |
| E&D | Engineering and Development Directorate, Johnson Space Center |
| E&I | Electrical and Instrumentation |
| E&OO | Engineering and Operations Office |
| E/C | Encoder/Coupler |
| E/L | Entry/Landing |
| E/M | Engineering Model |
| E/O | Engineering/Operations |
| E/O-IMS | Engineering/Operations - Information Management System |
| E/W | Energy to Weight Ratio |
| EA | EAch |