| Abbreviation | Definition |
|---|---|
| HSF | Hypergot Servicing Facility |
| HSFRS | High-Speed Flight Research Station (renamed NASA Dryden Flight Research Center) |
| HSG | High Sustained Gs acceleration |
| HSI | Horizontal Situation Indicator |
| HSI | Hot Surface Ignition |
| HSIO | High Speed Input/Output |
| HSK | Horizontal Sling Kit |
| HSL | Hardware Simulation Laboratory |
| HSNG | HouSiNG |
| HSP | Health Stabilization Program |
| HSP | High Speed Printer |
| HSR | Hardware Status Register |
| HSS | High Speed Reader |
| HSS | High Stress and Strain |
| HSS | Hydraulic Sub-system Simulator |
| HSSE | Health, Safety, Security, and Environmental |
| HST | Hubble Space Telescope |
| HSTP | Hard SToP |
| HSU | Helium Service Unit |
| HT | Heat Transfer |