| Abbreviation | Definition |
|---|---|
| LOE | Left Outboard Elevon |
| LOE | Life On Earth |
| LOE | Line of Effort |
| LOFAR | Low Frequency Acquisition and Ranging |
| LOFO | Low Frequency Oscillation |
| LOGO | Limit of Government Obligation |
| LOI | Loss On Ignition |
| LOI | Lunar Orbit Insertion |
| LOL | Limit Of Liability |
| LOLA | Lunar Orbiter Laser Altimeter |
| LOLI | Limited Operational-Life Items |
| LON | Launch On Need |
| LON | Longitude |
| LON | LPS Operations Network |
| LOR | Lunar Orbit Rendezvous |
| LORA | Level Of Repair Analysis |
| LORAN | LOng RAnge Navigation |
| LOS | Lift-Off Simulator |
| LOS | Loss Of Signal |
| LOS | Loss Of Synchronization |