| Abbreviation | Definition |
|---|---|
| LSID | Launch Sequence and Interlock Document |
| LSM | Life Science Module |
| LSMI | Logistics Support Management Information |
| LSO | Landing Support Officer |
| LSO | Large Solar Observatory |
| LSP | Least Significant Portion |
| LSPDF | Life Science Payloads Development Facility |
| LSR | Land Sea Rescue |
| LSR | Land/Sea Rescue |
| LSR | Launch Site Recovery |
| LSR | Launch Support Room |
| LSRA | Landing Systems Research Aircraft |
| LSRM | Life Science Research Module |
| LSS | Landing Separation Simulator |
| LSS | Landing, Separation Simulator |
| LSS | Life Support Subsystem |
| LSS | Life Support System |
| LSSF | Life Sciences Support Facility |
| LSSL | Life Sciences Space Laboratory |
| LSSM | Launch Site Support Manager |