| Abbreviation | Definition |
|---|---|
| MAC | Main Assistance Console |
| MAC | Maintenance Advisory Committee |
| MAC | Maximum Allowable Concentration |
| MAC | Maximum Concentration of Organics |
| MAC | Multiaccess Computer |
| MAC | Multi-Access Computer |
| MACDS | Monitor and Control Display System |
| MACE | Mechanical Antenna Control Electronics |
| MACH | Machine |
| MACH | Velocity Relative to the Speed of Sound |
| MACI | Monitor, Access, and Control Interface |
| MACO | Major Assembly Checkout |
| MACRO | Merge and Correlate Recorded Output (Program) |
| MACS | Modular Attitude Control System |
| MAD | Madrid, Spain, Spaceflight Tracking and Data Network station |
| MAD | Maintenance Analysis Data |
| MADC | Multiplexer Analog to Digital Converter |
| MADRE | Manufacturing Data Retrieval System |
| MADS | Modeling and Analysis Data Set |
| MADS | Modular Auxiliary Data Systems |