| Abbreviation | Definition |
|---|---|
| MSE | Medical Support Equipment |
| MSE | Mission Server Element |
| MSE | Mission Staff Engineer |
| MSEC | Master Separation Events Controller |
| MSF | Maintenance Source File |
| MSF | Manned Space Flight |
| MSFB | Magnetically Stabilized Fluidized Bed |
| MSFC | George C. Marshall Space Flight Center |
| MSFN | Manned Space Flight Network |
| MSFP | Manned Space Flight Program |
| MSG | Mechanical Subsystem Group |
| MSG | Mission Support Group |
| MSI | Maintenance Significant Items |
| MSI | MicroSatellite Instability |
| MSIA | Multispectral Image Analyzer |
| MSID | Measurement Stimulation identification |
| MSIS | Man-Systems Integration Standards |
| MSK | Manual Select Keyboard |
| MSL | Mars Science Laboratory |
| MSL | Mechanical System(s) Laboratory |