| Abbreviation | Definition |
|---|---|
| OTS | Operational Testing and Simulation |
| OTS | Orbiter Transporter System |
| OTT | Optional Team Targeting |
| OTU | Operational Training Unit |
| OTV | Operational Television |
| OTV | Orbiter Transfer Vehicle |
| OUP | OFS Uplink Processor |
| OUT | Orbiter Utilities Tray |
| OUT | Outlet |
| OUT | Output |
| OUTBD | Outboard |
| OV | Orbital Vehicle |
| OV | Orbiter Vehicle |
| OV | Oxygen Vent |
| OVAB | Orbital Vehicle Assembly Building |
| OVAM | Orbital Vehicle Assembly Mode |
| OVC | Optimized Vehicle Configuration |
| OVC | Oxidizer Vent Control |
| OVCO | Operational Voice Communication Office |
| OVCP | Orbital Vehicle Checkout Procedure |