| Abbreviation | Definition |
|---|---|
| SCL | Secondary Coolant Line |
| SCL | Secondary Coolant Loop |
| SCL | Specification Change Log |
| SCLM | Stability, Control, and Load Maneuvers |
| SCM | Site Configuration Message |
| SCM | Subsystem Configuration Management |
| SCM | Subsystem Configuration Monitoring |
| SCM | System Control Module |
| SCMB | Development Configuration Management Board |
| SCMP | System Contractor Management Plan |
| SCNP | Preliminary Specification Change Notice |
| SCNR | Scanner |
| SCO | Start CheckOut |
| SCO | Sub-Carrier Oscillator |
| SCO | Super Critical Oxygen |
| SCO | Switch Closure Out |
| SCOE | Special Checkout Equipment |
| SCOPE | Science Calibration and Onboard Performance Evaluator |
| SCOS | Subsystem Computer Operating System |
| SCP | Scanner Control Power |