| Abbreviation | Definition |
|---|---|
| SES | Space Engineering Spacecraft |
| SES | Special Emphasis Study |
| SES | Systems Engineering Simulation |
| SESA | Special Equipment Stowage Facility |
| SESAC | Space and Earth Sciences Advisory Committee |
| SESAME | Severe Environmental Storms and Mesoscale Experiment |
| SESC | Shuttle Events Sequential Control |
| SESL | Space Environmental Simulation Laboratory |
| SETI | Search for Extraterrestrial Intelligence |
| SETS | Shuttle Electrodynamic Tether System |
| SEU | Structure and Evolution of the Universe |
| SEUL | Support Equipment Utilization List |
| SEWP | Scientific & Engineering Workstation Procurement |
| SF | Safe |
| SF | Safe, R and QA (R&QA), and Protective Services (KSC Directorate) |
| SF | Safety Factor |
| SF | Safety, Reliability and Quality Assurance (R&QA), and Protective Services |
| SF | Scale Factor |
| SF | Selection Filter |
| SF | Signaling Frequency |