| Abbreviation | Definition |
|---|---|
| MC | Moved Centerline |
| MC | Mystery Car |
| MCA | Minimum Crossing Altitude |
| MCC | Maintenance Control Center |
| MCC | Micro Compact Car |
| MCC | Motor Control Center |
| MCC | MotorCycle Crash |
| MCDS | Modular Cargo Delivery System |
| MCF | Metroplex Control Facility |
| MCFS | Master Container Freight |
| MCI | Kansas City International Airport |
| MCIHT | Member of the Chartered Institute of Highways and Transportation |
| MCMIS | Motor Carrier Management Information System |
| MCO | Orlando International Airport |
| MCR | Medical Condition Report |
| MCR | Motor-Cycle Rickshaw |
| MCREGIS | Motor Carrier Regulation Information System |
| MCS | Mini Cooper S (type of car) |
| MCS | Monitor and Control Software |
| MCS | Motor Carrier Safety |