| Abbreviation | Definition |
|---|---|
| IUD | Intensely Ugly Dude |
| IUP | I'm Usually Partying |
| IUPAC | International Union of Pedantic and Annoying Chemists |
| IUPUI | It's a University Perpetually Under Investigation |
| IVD | Innovative Veterinary Diet |
| IVF | Im Vagina Friendly |
| IVL | Insane Vice Lords |
| IVLA | Four Letter Acronym |
| IW | Immortal War |
| IWB | Irritated White Boy |
| IWBB | I want a Big Bomb |
| IWCYSH | I Would Cuddle You So Hard |
| IWHBYD | I Would Have Been Your Daddy |
| IWO | It's Welbe's Organization |
| IWTSS | I Will Take Social Studies |
| IYDHANTSDSAAA | If You Don't Have Anything Nice To Say Don't Say Anything At All |
| IYE | In Your Eye |
| IYSTMYNTJAAASG | If You See This Message, You Need To Join An Acronym Addicted Support Group |
| J2W | Jump to Win |
| JA | Jack of Aces |