| Sanaa (2) | | - | Eastern African, Swahili | |
| Sauda | | - | Eastern African, Swahili | |
| Seble | | - | Eastern African, Amharic | |
| Sefu | | - | Eastern African, Swahili | |
| Sekai | | - | Southern African, Shona | |
| Sethunya | | - | Southern African, Tswana | |
| Shanice | | shə-NEES | African American (Modern) | |
| Shanika | | shə-NEE-kə | African American (Modern) | |
| Shaniqua | | shə-NEE-kwə | African American (Modern) | |
| Shelena | | - | African American (Rare) | |
| Sibonakaliso | | - | Southern African, Zulu | |
| Simba (1) | | - | Southern African, Shona | |
| Simba (2) | | - | Eastern African, Swahili | |
| Simisola | | - | Western African, Yoruba | |
| Sipho | | - | Southern African, Xhosa | |