| Abbreviation | Definition |
|---|---|
| SPC | Suicide Prevention Care |
| SPCC | St. Paul's Community Center |
| SPCF | Suicide Prevention Care Fund |
| SPCL | Society for Pidgin and Creole Linguistics |
| SPDR | Seattle Purebred Dog Rescue |
| SPEC | Standard Performance Evaluation Corporation |
| SPEC | Systems Performance Evaluation Cooperative |
| SPFT | Sussex Partnership Foundation Trust |
| SPG | Sir Philip Game Centre |
| SPHB | St. Peter's Home for Boys |
| SPI | Samaritan's Purse International |
| SPI | Software in the Public Interest |
| SPICE | Supportive Parents of Indian Children Everywhere |
| SPIG | Special Primary Interest Group |
| SPIR | Samaritan's Purse International Relief |
| SPLC | Southern Poverty Law Center |
| SPN | State Policy Network |
| SPNEA | Society for the Preservation of New England Antiquities |
| SPO | Strengthening Participatory Organisation |
| SPPS | Steam Powered Preservation Society |