| Abbreviation | Definition |
|---|---|
| SPC | Text to speech |
| SPC | WordPerfect Special Temporary file |
| SPD | Speedo Scalable font |
| SPEI | Standardized Precipitation Evapotranspiration Index |
| SPF | Slide Presentation File |
| SPG | Sprint Glossary |
| SPH | Sphere |
| SPIFF | Still Picture Interchange File Format Graphics |
| SPK | Spark Compressed file archive |
| SPL | Macromedia Splash file |
| SPL | Personal SPell Dictionary |
| SPL | Sample |
| SPL | Splint Compressed file archive |
| SPL | Spool file for printing |
| SPL | Sprint Customized printer driver |
| SPM | WordPerfect Data |
| SPOT | SPOT satellite image file - Bitmap graphics |
| SPP | Sprint Printer file |
| SPR | Generated executable screen file (FoxPro) |
| SPR | Sizzler Animation |