| Abbreviation | Definition |
|---|---|
| SPR | Spreadsheet |
| SPR | Sprint Document letter |
| SPR | Sprite graphics image |
| SPRITE | Animation (Sizzler) |
| SPS | OS/2 Database |
| SPS | Sprint Screen driver |
| SPS | SPSS language source code file |
| SPT | Data support file (MITAC disk/system management utility pack) |
| SPT | Spitbol language source code file |
| SPT | Split (one part of multi-part file) |
| SPT | Support file |
| SPU | Atari compressed Spectrum Utilities fileBitmap graphics |
| SPW | SigmaPlot Worksheet |
| SPX | FoxPro Compiled executable screen file |
| SPX | Screensaver |
| SQD | Squish message base |
| SQI | Squish message base index |
| SQL | SQL report or query |
| SQL | Squish message base last read pointers |
| SQX | SQX Archiver archive format |