| Abbreviation | Definition |
|---|---|
| SBX | Saber Battle X |
| SC | Sector Clear |
| SC2 | StarCraft 2 |
| SC-20K | Automatic weapon |
| SCD | Sega CD |
| SCD | Sonic CD |
| SCNE | Sim City Network Edition |
| SCP | Secure Contain Protect |
| SCR | Starcraft Rocks |
| SCS | Supercharged Counter Strike |
| SD | Spirit Dancer |
| S-Dance | Swords Dance |
| SDC | Shadow Dragon Clan |
| SDC | Star Dance Clip in Super Mario 64 |
| SDF | Sips Defense Force |
| SDGD | Sancta Domenica Gaming Day |
| SDI | Smash Directional Influence |
| SEGA | Sexually Enticing Gaming Arts |
| SEGA | Styling Entertainment Gaming of America |
| SEGA | Super Entertainment Gaming Action |