| Abbreviation | Definition |
|---|---|
| ISLE | Intelligent Speech and Language Environment |
| ISMF | Interactive Storage Management Facility |
| ISO | IEC ISO International Electrotechnical Committee |
| ISO | International Standards Organization |
| ISODE | ISO Development Environment |
| ISOS | Information Systems OutSource |
| ISP | Information Service Provider |
| ISPF | Interactive System Productivity Facility |
| ISPF/PDF | ISPF Program Development Facility |
| ISPO | Input, Storage, Process, and Output |
| ISR | Information Storage and Retrieval |
| ISR | Intermediate Session Routing |
| ISSE | Intel SIMD Streaming Extension |
| ISV | Illegal Selector Value |
| ITA | Information Technology Automation |
| ITAM | Information Technology Asset Management |
| ITAP | Information Technology for Active Perception |
| ITAP | Interim Technology Advice Panel |
| ITAT | Information Technology Architecture Team |
| ITB | Intermediate Transmission Block |