| Abbreviation | Definition |
|---|---|
| SOL | Set Operations Language |
| SOLAR | Sequential Oligogenic Linkage Analysis Routines |
| SOM | System Object Model |
| SOMA | Service-oriented Modelling and Architecture |
| SOMO | Small Office/Mobile Office |
| SONOS | Some Oscillations Never Oscillate Sinuously |
| SOP | Shared Object Parser |
| SOPC | System On a Programmable Chip |
| SOS | Senternet Online Support |
| SOS | Start Of Significance |
| SOUL | Smalltalk Open Unification Language |
| SOX | Schema for Object-oriented XML |
| SP | Space |
| SP | Stops Processing |
| SPA | Software Publishers Association |
| SPAM | Sad Pointless Annoying Messages |
| SPAM | Self Propelled Automatic Mail |
| SPARC | Scalar Processor ARChitecture |
| SPARC | Sun Processor Allowing Remote Capture |
| SPARC | Sunos Pipeline Accelerated Risc Computer |