| Abbreviation | Definition |
|---|---|
| COAX | CO-AXial |
| COB | Communications Office Building |
| COBE | COsmic Background Explorer (1989 satellite) |
| COBOL | COmmon Business-Oriented Language |
| COBRA | Co-Optimized Booster for Reusable Applications |
| COBS | Central On Board Software |
| COC | Close-Open-Close |
| COD | Center Operations Directorate |
| COD | Cockpit Only Deorbit |
| COE | Correction Of Error |
| COF | Central Operations Facility |
| COF | Columbus Orbital Facility |
| COF | Construction Of Facilities |
| COFI | CheckOut and Fault Isolation |
| COFR | Certificate Of Flight Readiness |
| COFW | Certificate Of Flight Worthiness |
| COI | Coast Orbital Insertion |
| COI | Composite Optics, Inc. |
| COI | Contingency Orbit Insertion |
| CO-I | Co Investigator |