| Abbreviation | Definition |
|---|---|
| COIM | CheckOut Interpreter Module |
| COL | CheckOut Language |
| COLBERT | Combined Operational Load-Bearing External-Resistance Treadmill |
| COLD-SAT | Cryogenic On-orbit Liquid Depot - Storage, Acquisition, Transfer |
| COLM | COLuMn |
| COM | COMmon |
| COM | Computer Output Microfiche |
| COMAS | Combined Orbital Maneuvering and Abort System |
| COMAT | COMpatibility of MATerials |
| COMB | Combination |
| COMB | COMBustion |
| COMBS | Combinations |
| COMEDS | COntinental United States MEteorological Data System |
| COM-M | COMmon Mode |
| COMMAND | Computer COMmand Engineer |
| COMP | COMPass |
| COMP | COMPensate |
| COMP | COMPonent |
| COMP | COMPutation (Rendezvous Targeting) |
| COMP | COMPuter |