| Abbreviation | Definition |
|---|---|
| COSI | CloseOut System Installation |
| COSMIC | Coherent Optical System of Modular Imaging Collectors |
| COSPAR | Committee On SPAce Research |
| COSS | Centaur Operations at the Space Station |
| COSTA | Cost Accounting |
| COSTEP | Comprehensive Supra Thermal and Energetic Particle Analyzer |
| COSTEP | Comprehensive Supra-Thermal and Energetic Particle Analyzer |
| COSTR | Collaborative Solar-Terrestrial Research |
| COTS | Commercial Orbital Transportation Services |
| COV | CutOff Valve |
| CP | Candle Power |
| CP | Cargo Program Office |
| CP | Center of Pressure |
| CP | Chemically Pure |
| CP | Circular Pitch |
| CP | Cold Plate |
| CP | Console Processor |
| CP | Control Panel |
| CP | Control Point |
| CP | Controlled Planetary |