| Abbreviation | Definition |
|---|---|
| SAC | Seriously Amusing Cat |
| SAC | Students Against Classes |
| SACRED | Suvisesha Ashram Christian Rural Education And Development |
| SAE | Silly Apes and Eagles |
| SAFE | Smurf Amplifier Finding Executive |
| SAGA | Send A Granny Away |
| SAGA | Send All Geriatrics Abroad |
| SAGA | Send All Grannies Away |
| SAGE | South Aiken Girls Excel |
| SAHM | Still A Hot Momma |
| SAIMA | Sharp Admirable Inspiring Magnificent Attractive |
| SALEM | Silk Aluminium Lithium Electricity Mango |
| SAM | Secret Agent Man |
| SAM | Secret Asian Man |
| SAM | Sidewalk Alpha Male |
| SAM | Slow As Molasses |
| SAM | Smart Ass Masochist |
| SAM | Strategically Altered Mutant |
| SAMPE | Singers Are Mad People in Entertainments |
| SAMPE | Some Artist Made Popular in Entertainments |