| Abbreviation | Definition |
|---|---|
| SKL | Saturday Knight Live |
| SKOTUS | Serial Killer Of The United States |
| SKS | Storm King School |
| SKYE | Sexy Kind Youthful Energetic |
| SKYPE | Someone Kalls, You Pay Everything |
| SL | Spirit Lady |
| SLAG | Screeches like a girl. |
| SLAG | Short Little Angry Guy |
| SLAK | Subgenius Liberation Army Korps |
| SLAM | Something Like Another Monday |
| SLAM | Surviving Life After Maryland |
| SLAP | Smells Like A Party |
| SLATFATF | So Long and Thanks For All the Fish |
| SLC | Salt Lick City |
| SLC | Stupid Little Compiler |
| SLEEP | Sentient Lapse Endemic Entropy Polarization |
| SLOPE | Smashed, Lost, Or Pulverized Eventually |
| SLOT | Secret Lives Of Toys |
| SLP | Simulated Livermore Phantom |
| SLR | Silly Little Ranger |