| Abbreviation | Definition |
|---|---|
| AFAG | Alliance for Accountable Governance |
| AFAM | African First Aid Materials |
| AFAO | Association France Afrique Orient (French: Association France-Africa-East; est. 1993) |
| AFCAC | AFrican Civil Aviation Commission |
| AFCAS | African Commission on Agricultural Statistics |
| AFCC | African Federation of Clinical Chemistry |
| AFCON | Africa Fought Corruption On Nations |
| AFCON | African Cup of Nations |
| AFDA | Africa Film Drama Art |
| AfDB | African Development Bank |
| AFDN | African Families Development Network |
| AFDT | African Football Dream Team |
| AFEC | African Future Earth Committee |
| AFEJ | African Federation of Environmental Journalists |
| AFEM | African Federation for Emergency Medicine |
| AFF | African Film Festival |
| AFF | African Freedom Fighters |
| AFFM | Africa Fertilizer Financing Mechanism |
| AFFT | African Freedom Fund Treasury |
| AFG | Africa Foresight Group |