| SINA | Sensor Information and Networking Architecture |
| SIP | Structural Insulated Panel |
| SIUPA | State Institute of Urban Planning and Architecture |
| SJI | Steel Joist Institute |
| SKA | Steven Kahle Architects |
| SL | Sky Light |
| SLV | Short Leg Vertical |
| SME | Scale Model Engineering |
| SMS | Spatial Management System |
| SNK | Sink |
| SNRA | Sensor Network Reference Architecture |
| SNSA | Scalable Network Simulator Architecture |
| SOA | Services Oriented Architecture |
| SOA | Service Oriented Architecture |
| SOA | Service Orientated Architecture |
| SOA | Same Old Architecture |
| SOA | Simon Oswald Architecture |
| SOAD | School of Architecture and Design |
| SOAF | Service Oriented Architecture Framework |
| SOAP | Services Oriented Architecture Protocol |